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UF Health University of Florida
Qian Lab Division of Hematology & Oncology, College of Medicine

Publications

  • 2020 FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.Nature communications. 11(1). [DOI] 10.1038/s41467-020-14590-9. [PMID] 32066721.View on: PubMed  · Publisher’s Site 
  • 2020 Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.Leukemia. 34(2):380-390. [DOI] 10.1038/s41375-019-0566-x. [PMID] 31492896.View on: PubMed  · Publisher’s Site 
  • 2020 RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.Cell stem cell. 27(1):64-80.e9. [DOI] 10.1016/j.stem.2020.04.009. [PMID] 32402250.View on: PubMed  · Publisher’s Site 
  • 2020 Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood. [DOI] 10.1182/blood.2019004688. [PMID] 32822452.View on: PubMed  · Publisher’s Site 
  • 2020 TFII-I/Gtf2i and Erythro-Megakaryopoiesis.Frontiers in physiology. 11. [DOI] 10.3389/fphys.2020.590180. [PMID] 33101065.View on: PubMed  · Publisher’s Site 
  • 2019 A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML.Molecular cancer. 18(1). [DOI] 10.1186/s12943-019-0952-z. [PMID] 30813931.View on: PubMed  · Publisher’s Site 
  • 2019 Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.Cancer cell. 35(4):677-691.e10. [DOI] 10.1016/j.ccell.2019.03.006. [PMID] 30991027.View on: PubMed  · Publisher’s Site 
  • 2018 Forkhead Box M1 Transcriptionally Regulates the Expression of Long Noncoding RNAs Snhg8 and Gm26917 to Promote Proliferation and Survival of Muscle Satellite Cells.Stem cells (Dayton, Ohio). 36(7):1097-1108. [DOI] 10.1002/stem.2824. [PMID] 29575305.View on: PubMed  · Publisher’s Site 
  • 2018 Genome-wide characterization of lncRNAs in acute myeloid leukemia.Briefings in bioinformatics. 19(4):627-635. [DOI] 10.1093/bib/bbx007. [PMID] 28203711.View on: PubMed  · Publisher’s Site 
  • 2018 METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.Cell stem cell. 22(2):191-205.e9. [DOI] 10.1016/j.stem.2017.11.016. [PMID] 29290617.View on: PubMed  · Publisher’s Site 
  • 2018 miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3.Scientific reports. 8(1). [DOI] 10.1038/s41598-018-24628-0. [PMID] 29695725.View on: PubMed  · Publisher’s Site 
  • 2018 YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6.Circulation research. 123(1):43-56. [DOI] 10.1161/CIRCRESAHA.118.313143. [PMID] 29794022.View on: PubMed  · Publisher’s Site 
  • 2017 Current Understanding of Inflammatory Responses in Acute Kidney Injury.Current gene therapy. 17(6):405-410. [DOI] 10.2174/1566523218666180214092219. [PMID] 29446733.View on: PubMed  · Publisher’s Site 
  • 2017 β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).Cancer research. 77(15):4116-4126. [DOI] 10.1158/0008-5472.CAN-17-0202. [PMID] 28611040.View on: PubMed  · Publisher’s Site 
  • 2016 Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.Haematologica. 101(6):e232-6. [DOI] 10.3324/haematol.2015.139527. [PMID] 26944478.View on: PubMed  · Publisher’s Site 
  • 2015 The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells.Nature immunology. 16(8):810-8. [DOI] 10.1038/ni.3204. [PMID] 26147687.View on: PubMed  · Publisher’s Site 
  • 2014 A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets.Scientific reports. 4. [DOI] 10.1038/srep07338. [PMID] 25475013.View on: PubMed  · Publisher’s Site 
  • 2014 Endothelial FoxM1 mediates bone marrow progenitor cell-induced vascular repair and resolution of inflammation following inflammatory lung injury.Stem cells (Dayton, Ohio). 32(7):1855-64. [DOI] 10.1002/stem.1690. [PMID] 24578354.View on: PubMed  · Publisher’s Site 
  • 2013 Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Blood. 121(20):4063-72. [DOI] 10.1182/blood-2012-12-473470. [PMID] 23547052.View on: PubMed  · Publisher’s Site 
  • 2013 Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America. 110(14):5594-9. [DOI] 10.1073/pnas.1302645110. [PMID] 23509296.View on: PubMed  · Publisher’s Site 
  • 2013 Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repressor and TALEN.Stem cell reports. 1(3):218-25. [DOI] 10.1016/j.stemcr.2013.07.002. [PMID] 24319658.View on: PubMed  · Publisher’s Site 
  • 2013 p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.Molecular oncology. 7(6):1069-82. [DOI] 10.1016/j.molonc.2013.07.011. [PMID] 23988911.View on: PubMed  · Publisher’s Site 
  • 2012 Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells.The Journal of biological chemistry. 287(27):22683-90. [DOI] 10.1074/jbc.M112.342089. [PMID] 22589536.View on: PubMed  · Publisher’s Site 
  • 2011 Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds.PloS one. 6(10). [DOI] 10.1371/journal.pone.0026592. [PMID] 22046312.View on: PubMed  · Publisher’s Site 
  • 2011 The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA.PloS one. 6(6). [DOI] 10.1371/journal.pone.0020793. [PMID] 21695170.View on: PubMed  · Publisher’s Site 
  • 2010 Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.Chemico-biological interactions. 184(1-2):50-7. [DOI] 10.1016/j.cbi.2009.11.025. [PMID] 19958752.View on: PubMed  · Publisher’s Site 
  • 2009 Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.Cell research. 19(3):296-306. [DOI] 10.1038/cr.2009.20. [PMID] 19238173.View on: PubMed  · Publisher’s Site 
  • 2008 A critical role for Apc in hematopoietic stem and progenitor cell survival.The Journal of experimental medicine. 205(9):2163-75. [DOI] 10.1084/jem.20080578. [PMID] 18725524.View on: PubMed  · Publisher’s Site 
  • 2008 Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Proceedings of the National Academy of Sciences of the United States of America. 105(40):15535-40. [DOI] 10.1073/pnas.0808266105. [PMID] 18832181.View on: PubMed  · Publisher’s Site 
  • 2007 MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America. 104(50):19971-6. [PMID] 18056805.View on: PubMed 
  • 2005 Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.The Journal of biological chemistry. 280(26):24931-40. [PMID] 15886202.View on: PubMed 
  • 2002 Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America. 99(23):14925-30. [PMID] 12417757.View on: PubMed