Publications » Qian Lab » College of Medicine

2023 Sep 5. MiR-9-1 controls osteoblastic regulation of lymphopoiesis. Yongguang Zhang^1 2, Danfeng Lin², Yongwei Zheng¹, Yuhong Chen¹, Mei Yu¹, Dongya Cui², Miaohui Huang², Xinlin Su³, Yong Sun^4 5, Yabing Chen^4 5, Zhijian Qian⁶, Karen-Sue Carlson^1 7, Renren Wen^8 9, Demin Wang^10 11. Leukemia. doi: 10.1038/s41375-023-02014-8.
2023 Aug. Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice. Chunjie Yu^1 2, Yue Sheng^1 2 3, Fang Yu^1 2, Hongyu Ni⁴, Alan Qiu^1 2, Yong Huang⁵, Zhijian Qian^1 2. Journal of Clinical Investigation. 1;133(15):e163911. doi: 10.1172/JCI163911.
2023 Jun 15. Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies. Fang Yu^1 2, Zhijian Qian^1 2. Journal of Clinical Investigation. 33(12):e171104. doi: 10.1172/JCI171104.
2023 Jun 15. RBM33 is a unique m⁶A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity. Fang Yu¹, Allen C Zhu², Shun Liu², Boyang Gao², Yuzhi Wang³, Nelli Khudaverdyan⁴, Chunjie Yu⁵, Qiong Wu⁵, Yunhan Jiang⁶, Jikui Song⁴, Lingtao Jin⁶, Chuan He⁷, Zhijian Qian⁸. Molecular Cell. 83(12):2003-2019.e6.doi: 10.1016/j.molcel.2023.05.010.
2023 Mar 29. Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia. Zhenhua Chen¹, Keren Zhou¹, Jianhuang Xue^1 2, Andrew Small¹, Gang Xiao^1 3 4, Le Xuan Truong Nguyen^5 6, Zheng Zhang¹, Emily Prince¹, Hengyou Weng^1 7, Huilin Huang^1 8, Zhicong Zhao^1 9, Ying Qing¹, Chao Shen¹, Wei Li¹, Li Han¹, Brandon Tan¹, Rui Su¹, Hanjun Qin¹⁰, Yangchan Li^1 11, Dong Wu¹, Zhaohui Gu^1 12, Vu N Ngo¹, Xin He⁵, Jianfei Chao¹³, Keith Leung¹, Kitty Wang¹, Lei Dong¹, Xi Qin¹, Zhenming Cai^1 14, Yue Sheng^15 16, Yu Chen¹⁷, Xiwei Wu¹⁰, Bin Zhang^5 6, Yanhong Shi¹³, Guido Marcucci^5 6, Zhijian Qian¹⁵, Mingjiang Xu¹⁸, Markus Müschen^1 19, Jianjun Chen^1 6, Xiaolan Deng¹. Science Translational Medicine. 15(689):eabq8513. doi: 10.1126/scitranslmed.abq8513.
2023 Mar 28. m⁶A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts. Zheng Zhang^1 2, Keren Zhou¹, Li Han^1 3, Andrew Small¹, Jianhuang Xue^1 4, Huilin Huang^1 5, Hengyou Weng^1 6 7, Rui Su¹, Brandon Tan¹, Chao Shen¹, Wei Li¹, Zhicong Zhao^1 8, Ying Qing¹, Xi Qin^1 2, Kitty Wang¹, Keith Leung¹, Mark Boldin¹, Chun-Wei Chen¹, David Ann^2 9, Zhijian Qian¹⁰, Xiaolan Deng¹, Jianjun Chen^1 11, Zhenhua Chen¹. Genes & Diseases. 11(1):382-396. doi: 10.1016/j.gendis.2023.01.016.
2022 Sep. Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency. Stephen J Staklinski¹, Mario C Chang¹, Fang Yu², Kathleen Collins Ruff³, David N Franz⁴, Zhijian Qian², Linda B Bloom¹, Matthew E Merritt¹, Robert McKenna¹, Michael S Kilberg⁵. The Journal of Biological Chemistry. 298(9):102385. doi: 10.1016/j.jbc.2022.102385.
2022 Aug. m⁶A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts. Qinglin Dang¹, Qiong Wu¹, Fang Yu², Yue Sheng², Chunjie Yu³, Guangzhong Song⁴, Kimberly Paulsen³, Jianxin Lyu⁵, Zhijian Qian⁶. Haematologica. 1;107(8):1922-1927. doi: 10.3324/haematol.2021.279300.
2021 Dec 30. A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication. Yue Sheng¹, Jiangbo Wei^2 3, Fang Yu¹, Huanzhou Xu⁴, Chunjie Yu¹, Qiong Wu¹, Yin Liu¹, Lei Li^5 6, Xiao-Long Cui^2 3, Xueying Gu⁷, Bin Shen⁷, Wei Li⁵, Yong Huang⁸, Sumita Bhaduri-McIntosh^4 9, Chuan He^2 3, Zhijian Qian¹. Blood. 138(26):2838-2852. doi: 10.1182/blood.2021011707.
2021 Jun 4. Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response. Fang Yu^1 2, Jiangbo Wei^3 4, Xiaolong Cui^3 4, Chunjie Yu¹, Wei Ni⁵, Jörg Bungert², Lizi Wu⁵, Chuan He^3 4, Zhijian Qian^1 2.Nucleic Acids Res.;49(10):5779-5797. doi: 10.1093/nar/gkab415.
2021 Feb 4. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Yue Sheng^1 2 1, Rui Ma³, Chunjie Yu^1 2 1 3, Qiong Wu^1 2 1 3, Steven Zhang⁴, Kimberly Paulsen^1 2, Jiwang Zhang⁵, Hongyu Ni⁶, Yong Huang⁷, Yi Zheng⁸, Zhijian Qian^1 2 1. Blood. 137(5):610-623. doi: 10.1182/blood.2019004688.
2020 FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML. Nature communications. 11(1). [DOI] 10.1038/s41467-020-14590-9. [PMID] 32066721.View on: PubMed · Publisher’s Site
2020 Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.Leukemia. 34(2):380-390. [DOI] 10.1038/s41375-019-0566-x. [PMID] 31492896.View on: PubMed · Publisher’s Site
2020 RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.Cell stem cell. 27(1):64-80.e9. [DOI] 10.1016/j.stem.2020.04.009. [PMID] 32402250.View on: PubMed · Publisher’s Site
2020 Role of c-Myc haploinsufficiency in the maintenance of HSCs.Blood. [DOI] 10.1182/blood.2019004688. [PMID] 32822452.View on: PubMed · Publisher’s Site
2020 TFII-I/Gtf2i and Erythro-Megakaryopoiesis.Frontiers in physiology. 11. [DOI] 10.3389/fphys.2020.590180. [PMID] 33101065.View on: PubMed · Publisher’s Site
2019 A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML.Molecular cancer. 18(1). [DOI] 10.1186/s12943-019-0952-z. [PMID] 30813931.View on: PubMed · Publisher’s Site
2019 Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.Cancer cell. 35(4):677-691.e10. [DOI] 10.1016/j.ccell.2019.03.006. [PMID] 30991027.View on: PubMed · Publisher’s Site
2018 Forkhead Box M1 Transcriptionally Regulates the Expression of Long Noncoding RNAs Snhg8 and Gm26917 to Promote Proliferation and Survival of Muscle Satellite Cells.Stem cells (Dayton, Ohio). 36(7):1097-1108. [DOI] 10.1002/stem.2824. [PMID] 29575305.View on: PubMed · Publisher’s Site
2018 Genome-wide characterization of lncRNAs in acute myeloid leukemia.Briefings in bioinformatics. 19(4):627-635. [DOI] 10.1093/bib/bbx007. [PMID] 28203711.View on: PubMed · Publisher’s Site
2018 METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.Cell stem cell. 22(2):191-205.e9. [DOI] 10.1016/j.stem.2017.11.016. [PMID] 29290617.View on: PubMed · Publisher’s Site
2018 miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3.Scientific reports. 8(1). [DOI] 10.1038/s41598-018-24628-0. [PMID] 29695725.View on: PubMed · Publisher’s Site
2018 YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6.Circulation research. 123(1):43-56. [DOI] 10.1161/CIRCRESAHA.118.313143. [PMID] 29794022.View on: PubMed · Publisher’s Site
2017 Current Understanding of Inflammatory Responses in Acute Kidney Injury.Current gene therapy. 17(6):405-410. [DOI] 10.2174/1566523218666180214092219. [PMID] 29446733.View on: PubMed · Publisher’s Site
2017 β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).Cancer research. 77(15):4116-4126. [DOI] 10.1158/0008-5472.CAN-17-0202. [PMID] 28611040.View on: PubMed · Publisher’s Site
2016 Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.Haematologica. 101(6):e232-6. [DOI] 10.3324/haematol.2015.139527. [PMID] 26944478.View on: PubMed · Publisher’s Site
2015 The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells.Nature immunology. 16(8):810-8. [DOI] 10.1038/ni.3204. [PMID] 26147687.View on: PubMed · Publisher’s Site
2014 A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets.Scientific reports. 4. [DOI] 10.1038/srep07338. [PMID] 25475013.View on: PubMed · Publisher’s Site
2014 Endothelial FoxM1 mediates bone marrow progenitor cell-induced vascular repair and resolution of inflammation following inflammatory lung injury.Stem cells (Dayton, Ohio). 32(7):1855-64. [DOI] 10.1002/stem.1690. [PMID] 24578354.View on: PubMed · Publisher’s Site
2013 Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Blood. 121(20):4063-72. [DOI] 10.1182/blood-2012-12-473470. [PMID] 23547052.View on: PubMed · Publisher’s Site
2013 Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America. 110(14):5594-9. [DOI] 10.1073/pnas.1302645110. [PMID] 23509296.View on: PubMed · Publisher’s Site
2013 Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repressor and TALEN.Stem cell reports. 1(3):218-25. [DOI] 10.1016/j.stemcr.2013.07.002. [PMID] 24319658.View on: PubMed · Publisher’s Site
2013 p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.Molecular oncology. 7(6):1069-82. [DOI] 10.1016/j.molonc.2013.07.011. [PMID] 23988911.View on: PubMed · Publisher’s Site
2012 Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells.The Journal of biological chemistry. 287(27):22683-90. [DOI] 10.1074/jbc.M112.342089. [PMID] 22589536.View on: PubMed · Publisher’s Site
2011 Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds.PloS one. 6(10). [DOI] 10.1371/journal.pone.0026592. [PMID] 22046312.View on: PubMed · Publisher’s Site
2011 The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA.PloS one. 6(6). [DOI] 10.1371/journal.pone.0020793. [PMID] 21695170.View on: PubMed · Publisher’s Site
2010 Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.Chemico-biological interactions. 184(1-2):50-7. [DOI] 10.1016/j.cbi.2009.11.025. [PMID] 19958752.View on: PubMed · Publisher’s Site
2009 Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.Cell research. 19(3):296-306. [DOI] 10.1038/cr.2009.20. [PMID] 19238173.View on: PubMed · Publisher’s Site
2008 A critical role for Apc in hematopoietic stem and progenitor cell survival.The Journal of experimental medicine. 205(9):2163-75. [DOI] 10.1084/jem.20080578. [PMID] 18725524.View on: PubMed · Publisher’s Site
2008 Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Proceedings of the National Academy of Sciences of the United States of America. 105(40):15535-40. [DOI] 10.1073/pnas.0808266105. [PMID] 18832181.View on: PubMed · Publisher’s Site
2007 MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America. 104(50):19971-6. [PMID] 18056805.View on: PubMed
2005 Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.The Journal of biological chemistry. 280(26):24931-40. [PMID] 15886202.View on: PubMed
2002 Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America. 99(23):14925-30. [PMID] 12417757.View on: PubMed